Saponaro, D. Bauer, M. Hunter Giese, P. Swuec, A. Porro, F. Gasparri, A. Sadat Sharifzadeh, A. Chaves-Sanjuan, L. Alberio, Giacomo Parisi, Gabriele Cerutti, Oliver B. Clarke, Kay Hamacher, H.M. Colecraft, F. Mancia, W. A. Hendrickson, S.A. Siegelbaum, D DiFrancesco, M. Bolognesi, G. Thiel, B. Santoro, A. Moroni. Gating movements and ion permeation in HCN4 pacemaker channels. Mol. Cell, accepted, 2021.

Anja J. Engel, Marina Kithil, Markus Langhans, Oliver Rauh, Matea Cartolano, James L. Van Etten, Anna Moroni and Gerhard Thiel. Codon Bias Can Determine Sorting of a Potassium Channel Protein. Cells 2021,10, 1128.

Winterstein LM, Kukovetz K, Hansen UP, Schroeder I, Van Etten JL, Moroni A, Thiel G, Rauh O. Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function. J Gen Physiol. 2021 Feb 1;153(2):e202012731. doi: 10.1085/jgp.202012731.

Michael Schmidt, Indra Schroeder, Daniel Bauer, Gerhard Thiel, Kay Hamacher. Inferring functional units in ion channel pores via relative entropy. Eur Biophys J. 2021 Jan;50(1):37-57. doi: 10.1007/s00249-020-01480-7. Epub 2021 Feb 1.


Anja J Engel, Laura-Marie Winterstein, Marina Kithil, Markus Langhans, Anna Moroni, Gerhard Thiel. Light-Regulated Transcription of a Mitochondrial-Targeted K+ Channel. Cells 2020, 9(11), 2507;

Kerri Kukovetz, Brigitte Hertel, Christopher R Schvarcz, Andrea Saponaro, Mirja Manthey, Ulrike Burk, Timo Greiner, Grieg F Steward, James L Van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh. A Functional K+ Channel from Tetraselmis Virus 1, a Member of the Mimiviridae. Viruses 2020, 12(10), 1107;

Janine D Brunner, Roman P Jakob, Tobias Schulze, Yvonne Neldner, Anna Moroni, Gerhard Thiel, Timm Maier, Stephan Schenck. Structural basis for ion selectivity in TMEM175 K+ channels. eLife 2020;9:e53683 doi: 10.7554/eLife.53683.

Tina Jenewein, Scott A Kanner, Daniel Bauer, Brigitte Hertel, Henry M Colecraft, Anna Moroni, Gerhard Thiel, Silke Kauferstein. The mutation L69P in the PAS domain of the hERG potassium channel results in LQTS by trafficking deficiency. Channels (Austin). 2020 Dec;14(1):163-174. doi: 10.1080/19336950.2020.1751522.

M. Chighizola, A. Previdi,T. Dini, C. Piazzoni, C. Lenardi, P. Milani, C. Schulte and A. Podestà. Adhesion force spectroscopy with nanostructuredcolloidal probes reveals nanotopography-dependent early mechanotransductive interactionsat the cell membrane level. Nanoscale. 2020 Jul 3. doi: 10.1039/d0nr01991g.!divAbstract

Murry CR, Agarkova IV, Ghosh JS, Fitzgerald FC, Carlson RM, Hertel B, Kukovetz K, Rauh O, Thiel G, Van Etten JL. Genetic Diversity of Potassium Ion Channel Proteins Encoded by Chloroviruses That Infect Chlorella heliozoae. Viruses. 2020 Jun 23;12(6):678. doi: 10.3390/v12060678. PMID: 32585987.


Porro, A. Saponaro, F. Gasparri, D. Bauer, C. Gross, M. Pisoni, G. Abbandonato, K. Hamacher, B. Santoro, G. Thiel, A. Moroni. The HCN domain couples voltage gating and cAMP response in Hyperpolarization-activated Cyclic Nucleotide-gated channels. eLife 2019;8:e49672.

Khoury ME, Winterstein T, Weber W, Stein V, Schlaak HF, Thiel G. Photolithographic Fabrication of Micro Apertures in Dry Film Polymer Sheets for Channel Recordings in Planar Lipid Bilayers. J Membr Biol. 2019 Mar 12. doi: 10.1007/s00232-019-00062-9.

Hartel AJW, Shekar S, Ong P, Schroeder I, Thiel G, Shepard KL. High bandwidth approaches in nanopore and ion channel recordings – A tutorial review. Anal Chim Acta. 2019 Jul 11;1061:13-27. doi: 10.1016/j.aca.2019.01.034. Epub 2019 Jan 25.

Denise Eckert, Tobias Schulze, Julian Stahl, Oliver Rauh, James L Van Etten, Brigitte Hertel. A small viral potassium ion channel with an inherent inward rectification. Channels, 2019, 13(1), pp. 124–135.


C. Marini, A. Porro, A. Rastetter, C. Dalle, I. Rivolta, D. Bauer, R Oegema, C Nava, E. Parrini, D. Mei, C. Mercer, R. Dhamija, C. Chambers, C. Coubes, J. Thevenon, P. Kuentz, S. Julia, L. Pasquier, C. Dubourg, W. Carre, A. Rosati, F. Melani, T. Pisano, M. Giardino, A.M. Innes, Y. Alembik, S. Scheidecker, M. Santos, S. Figueiroa, C. Garrido, C. Fusco, D. Frattini, C. Spagnoli, A. Binda, T. Granata, F. Ragona, E. Freri, S. Franceschetti, L. Canafoglia, B. Castellotti, C. Gellera, R. Milanesi, M.M. Mancardi, D.R. Clark, F. Kok, K.L. Helbig, S. Ichikawa, L. Sadler, J. Neupauerova, P. Lasuthova, K. Sterbova, A. Laridon, E. Brilstra, B. Koeleman, J.R. Lemke, F. Zara, P. Striano, A. Barbuti, D. DiFrancesco, E. LeGuern, R. Guerrini, B. Santoro, K. Hamacher, G. Thiel, A. Moroni, J.C. DiFrancesco, C. Depienne. HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond. Brain 141(11):3160-3178, 2018.

*C. Gross, A. Saponaro, B. Santoro, A. Moroni, G. Thiel, K. Hamacher. Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide-gated cation channel. J Biol Chem. 2018 Aug 17;293(33):12908-12918. doi: 10.1074/jbc.RA118.002139.

Alberio L, Locarno A, Saponaro A, Romano E, Bercier V, Albadri S, Simeoni F, Moleri S, Pelucchi S, Porro A, Marcello E, Barsotti N, Kukovetz K, Boender AJ, Contestabile A, Luo S, Moutal A, Ji Y, Romani G, Beltrame M, Del Bene F, Di Luca M, Khanna R, Colecraft HM, Pasqualetti M, Thiel G, Tonini R, Moroni A. A light-gated potassium channel for sustained neuronal inhibition. Nat Methods. 2018 Nov;15(11):969-976. doi: 10.1038/s41592-018-0186-9. Epub 2018 Oct 30.

Rauh O, Hansen UP, Scheub DD, Thiel G, Schroeder I. Site-specific ion occupation in the selectivity filter causes voltage-dependent gating in a viral K+ channel. Sci Rep. 2018 Jul 10;8(1):10406. doi: 10.1038/s41598-018-28751-w.

V. Rondelli, E. Del Favero, P. Brocca, G. Fragneto, M. Trapp, L. Mauri, M.G. Ciampa, G. Romani, C.J. Braun, L. Winterstein, I. Schroeder, G. Thiel, A. Moroni, L. Cantu’. Directional K+ channel insertion in a single phospholipid bilayer: Neutron reflectometry and electrophysiology in the joint exploration of a model membrane functional platform. BBA – General Subjects 1862 (2018) 1742–1750.

Saponaro A, Cantini F, Porro A, Bucchi A, DiFrancesco D, Maione V, Donadoni C, Introini B, Mesirca P, Mangoni ME, Thiel G, Banci L, Santoro B, Moroni A. A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Elife. 2018 Jun 20;7. pii: e35753. doi: 10.7554/eLife.35753.

Gross C, Saponaro A, Santoro B, Moroni A, Thiel G, Hamacher K. Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide-gated cation channel. J Biol Chem. 2018 Aug 17;293(33):12908-12918. doi: 10.1074/jbc.RA118.002139. Epub 2018 Jun 23.

Winterstein LM, Kukovetz K, Rauh O, Turman DL, Braun C, Moroni A, Schroeder I, Thiel G. Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers. J Gen Physiol. 2018 Apr 2;150(4):637-646. doi: 10.1085/jgp.201711904. Epub 2018 Feb 27.

Hartel AJW, Ong P, Schroeder I, Giese MH, Shekar S, Clarke OB, Zalk R, Marks AR, Hendrickson WA, Shepard KL. Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1789-E1798. doi: 10.1073/pnas.1712313115. Epub 2018 Feb 5.

Timo Greiner, Anna Moroni, James L Van Etten and Gerhard Thiel. Genes for Membrane Transport Proteins: Not So Rare in Viruses. Viruses 2018, 10(9), 456;


Rauh O, Hansen UP, Mach S, Hartel AJW, Shepard KL, Thiel G, Schroeder I. Extended beta distributions open the access to fast gating in bilayer experiments-assigning the voltage-dependent gating to the selectivity filter. FEBS Lett. 2017 Dec;591(23):3850-3860. doi: 10.1002/1873-3468.12898.

Saponaro A, Porro A, Chaves-Sanjuan A, Nardini M, Rauh O, Thiel G, Moroni A. Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell. 2017 Oct;29(10):2570-2580. doi: 10.1105/tpc.17.00375.

Rauh O, Urban M, Henkes LM, Winterstein T, Greiner T, Van Etten JL, Moroni A, Kast SM, Thiel G, Schroeder I. Identification of Intrahelical Bifurcated H-Bonds as a New Type of Gate in K+ Channels. J Am Chem Soc. 2017 Jun 7;139(22):7494-7503. doi: 10.1021/jacs.7b01158.

Cosentino C, Alberio L, Thiel G, Moroni A. Yeast-Based Screening System for the Selection of Functional Light-Driven K+ Channels. Methods Mol Biol. 2017;1596:271-285. doi: 10.1007/978-1-4939-6940-1_17.

Weißgraeber S, Saponaro A, Thiel G, Hamacher K. A reduced mechanical model for cAMP-modulated gating in HCN channels. Sci Rep. 2017 Jan 11;7:40168. doi: 10.1038/srep40168.